【摘要】 目的:研究检测非小细胞肺癌(NSCLC)患者外周血Lunx mRNA表达对于诊断肿瘤微转移的临床价值。方法:采用荧光定量RT-PCR技术,对42例NSCLC患者及18例良性肺部疾病患者外周血Lunx mRNA进行检测。结果:NSCLC患者外周血Lunx mRNA表达的阳性率为40.5%(17/42),I~Ⅱ期NSCLC患者的阳性率为18.8%(3/16),Ⅲ期患者的阳性率为47.1%(8/17),Ⅳ期患者阳性率为66.7%(6/9),而肺部良性疾病患者外周血无1例阳性表达。结论:检测外周血Lunx mRNA表达可作为诊断早期NSCLC患者微转移的一个参考指标。更多还原

【Abstract】 Objective: To study the clinical value of expressions of Lunx mRNA in the peripheral blood of patients with non-small cell lung cancer(NSCLC) for diagnosing micrometastasis.Methods: Fluorescent quantitation PCR was used to detect the expressions of Lunx mRNA in peripheral blood samples from 42 patients with NSCLC and 18 patients with benign pulmonary lesion. Results: The positive expression of Lunx mRNA was 40.5%(17/42) in peripheral blood of patients with NSCLC.Positive rates of Lunx mRNA in stage I~Ⅱ,stage Ⅲ,and stage Ⅳ patients was 18.8%(3/16),47.1%(8/17) and 66.7%(6/9) respectively.None of patients with benign pulmonary disease had positive expression of Lunx mRNA. Conclusion: he expressions of Lunx mRNA in peripheral blood can be used as diagnostic biomarkers of micrometastasis in patients with NSCLC.更多还原