【摘要】 [目的]探讨酒精性晚期股骨头坏死与长期、过量饮酒的关系。[方法]回顾本院165例人工全髋关节置换病例。分析其中27例酒精性晚期股骨头坏死的临床资料,结合文献复习,探讨酒精性股骨头坏死的发病机理。长期大量饮酒与股骨头缺血性坏死、血液生化学和凝血功能等之间的关系。比较文献报道的实验结果有何异同。[结果]大量长期饮酒可导致股骨头坏死,是多方面因素综合的结果;日均饮酒750 m l以上者,有发生晚期双侧或单侧股骨头坏死的危险;血液生化观察指标无明显改变,但与凝血功能降低有关;股骨头坏死与髋关节的骨性关节炎可同时发生。[结论]长期大量饮酒,日均饮酒量大于750 m l以上者,有导致股骨头坏死的可能;血液生化的改变无特异性的意义;坏死的严重程度与酒量多少、时间长短有关;酒精性股骨头缺血性坏死的晚期患者,行人工全髋关节置换应是最佳选择,但这类患者术中术后有渗血较多的倾向。更多还原

【Abstract】 [Objective]To discuss the relation-ship between AAONFH(advanced alcoholic osteonecrosis of femoral head)and extended overdose drinking.[Method]Reviewed 165 cases of total hip arthroplasty,to analyzed the clinical data among 27 AAONFH cases,reviewed the literatures,discussed the pathogenesis of AAONFH and the relation-ship between blood biochemistry and blood cloting funtion and compared the experimental results among literatures.[Result]Theres various factors resulted in osteonecrosis of the femoral head associated with alcohol long-term over intake.Individuals consuming more than 750 ml of alcohol daily were at greater risk of double or half ONFH,Theres no change in biochemical test,but blood clotting funtion in this case would degrade,osteoarthritis of hip would synchronize.[Conclusion]Individuals consuming more than 750 ml of alcohol daily have the potentiality of ONFH;Its no specificity significance in biochemical test,the necrosis extent of the femoral head is relative to the capacity and times of alcohol intake.THR(total hip replacement)is the best treatment for AAONFH,but theres more staxis potentiality in this cases.更多还原