【摘要】 目的探讨外周血监测失血性休克患者肠道黏膜屏障功能的临床意义。方法选择失血性休克患者46例,分别在液体复苏前和液体复苏后1、3、8h抽肘静脉血4mL,测定二胺氧化酶(diamine oxidase,DAO)、胃动素(motilin,MTL)和内毒素(lipopolysaccharide,LPS),并设对照组。结果失血性休克患者血浆中DAO和MTL水平明显升高,各监测点持续升高,与对照组比较差异有统计学意义(P＜0．01)；而血浆LPS水平在各监测点都能监测到,但以液体复苏后第8小时最为明显,与对照组比较差异有统计学意义(P＜0．01)。伴有器官功能障碍的患者DAO、MTL和LPS水平比不伴有器官功能障碍的患者明显增高(P＜0．01或P＜0．05)。结论测定外周血血浆DAO与MTL水平能较好地反映失血性休克患者肠道黏膜屏障功能的状态。更多还原

【Abstract】 Objective To investigate the clinical significance of the use of peripheral venous blood as a means of monitoring intestinal mucosal barrier function in the patients with hemorrhagic shock.Methods 46 patients with hemorrhagic shock were recrui- ted.Healthy individuals were used as controls.4 mL blood was withdrawn before fluid resuscitation and at 1,3 and 8 hours after fluid resuscitation from the elbow vein of each subject for the determination of diamine oxidase(DAO),motilin(MTL)and lipopolysaccha- ride(LPS)in plasma.Results Plasma levels of DAO and MTL were increased at the various time points and were found to be signifi- cantly higher in the patients with hemorrhagic shock than in the control group(P＜0.01).Plasma LPS level could be detected at the various time points and the level was the highest at 8 hours after fluid resuscitation.Plasma LPS level was significantly higher in the pa- tients with hemorrhagic shock than in the control group(P＜0.01).Plasma DAO,MTL and LPS levels were significantly higher in the group with organ malfunction than in the group with normal organ(P＜0.01,P＜0.05).Conclusion Plasma DAO and MTL levels of peripheral venous blood could better reflect the intestinal mucosal barrier function in the patients with hemorrhagic shock.更多还原