【摘要】 目的探讨心肺复苏后病人血管紧张肽Ⅱ(AngⅡ)的变化及其意义。方法①对84例危重病人分为急诊心肺复苏组(A组,41例)和非心肺复苏组(B组,43例),另设正常对照组(C组,35例)。②A、B组病人于住院后第1、3、5和7天晨7∶30测定AngⅡ的浓度(C组仅做一次),同时记录平均动脉血压和发生心律失常等情况。结果①A、B组的AngⅡ均显著高于C组(P<0.01),而A组更高于B组(P<0.01)。②死亡病人不同时期AngⅡ明显高于存活者(P<0.01),而平均动脉血压均显著低于存活者(P<0.05或P<0.01)。③死亡者不同时期发生快速型室上性、室性心律失常均比存活者显著增多(P<0.05或P<0.01)。结论心跳呼吸骤停心肺复苏后病人体内始终存在AngⅡ升高,且微循环严重障碍,易发生再灌注心律失常,病情严重,预后差。AngⅡ可作为评估心肺复苏后病人预后的有效指标。更多还原

【Abstract】 Objective To explore the meaning of the angiotensin Ⅱ(AngⅡ) change in patients with cardiopulmonary resuscitation(CPR).Methods ① 84 critical patients were divided into different groups(Group A,41 emergency patients with CPR;Group B,43 criticall patients without CPR) and 35 normal people(Group C) were selected for comparism.②Observed the changes of the AngⅡ,mean blood pressure(MBP) and arrhythmia in group A and group B on 1,3,5 and 7 days after admission.Plasma levels of AngⅡ in 35 normal people were measured only.Result ① On 1,3,5and 7 days after admission,plasma levels of AngⅡ in group A and B patients were significantly higher than those in group C(P<0.01),and AngⅡ in group A were markedly higher than that in group B(P<0.01).② On defferent period,the AngⅡ in death patients were significantly higher than those in survival persons(P<0.01);but MBP in death patients were conspicuously lower than those in survival persons(P<0.05 or P<0.01).③ On defferent period,higher incidences of supraventricular and ventricular tachyarrhythmia in death patients were significantly higher than those in survival patients(P<0.05 or P<0.01).Conclusions Plasma level of AngⅡ after successful CPR is always very high, and microcirculation is failure,easily take place reperfusion arrhythmia.AngⅡ may be used to evaluate prognosis of cardiopulmonary resuscitation patients.更多还原