【摘要】 目的观察脑胶质瘤病的临床、病理、磁共振成像(MRI)特征。方法对本院近5年间收治的66例脑胶质瘤病患者进行分析。结果该病主要临床表现为进行性加重的头痛、呕吐等颅内压力增高,并伴有反复发作智能与精神障碍、癫痫、偏瘫等症状。影像学显示病变弥散,并灰白质均受累,占位效应不明显。病理检查示肿瘤细胞在大脑半球灰白质中广泛增殖,主要在血管、神经元周围呈浸润性生长,不形成团块。病理学所见:镜下病变区可见多数星形胶质瘤细胞呈弥漫性浸润性生长,细胞核有圆形、椭圆形,核染色较深,少见核分裂。其中58例患者行开颅切除手术,无手术死亡病例。结论脑胶质瘤病的临床表现与影像学结合可帮助诊断,但确诊仍需靠病理学检查。更多还原

【Abstract】 Objective To investigate the clinical manifestation,radiological manifestation and pathological characters of gliomatosis cerebri(GC).Methods Clinical studies of manifestation,radiological manifestation and pathological sections characters in 66 cases with GC(1999～2004) were analyzed.Results The main clinical manifestations of 3 patients were progressive headache,intracrannial hypertension,and mental retardation or dementia epilepsy,and hemisparesis.Radiological examination revealed diffuse lesions involved both hemispheres and without formation of a tumormass.Histological examination show that the tumour cells diffusely infiltrated cerebral hemispheres with perineural,perivascular involment,but no masses were formed.Fifty eight patients under went partially surgical remorval of the tumor lesions and no patients died in the operation.Conclusion The clinical and radiological features are helpful in diagnosis of GC,however the confirmation should depend on brain biopsisneeded.更多还原