【摘要】 目的探讨冠心病介入治疗的效果及对血管内皮生长因子(VEGF)和C-反应蛋白(CRP)水平的影响。方法127例心绞痛和心肌梗死患者,行PCI(PTCA/PTCA+支架术),观察疗效,测定CRP和VEGF在手术前后的变化。结果127例患者共安置支架146枚,支架全部成功地置入靶血管病变部位;有2例双支病变患者因导丝不能通过前降支狭窄部位放弃,4例患者发生无再流现象,手术成功率为95.3%。CRP的水平术后增加142.9%,而VEGF术后减少31.9%。结论PCI对冠心病的治疗效果是满意的,监测血清中CRP和VEGF可了解治疗效果和炎症程度。更多还原

【Abstract】 Objective To investigate the therapeutic efficacy of coronary heart disease intervention and effect on vascular endothelial growth factor(VEGF) and C-reactive protein(CRP) levels.Methods 127 cases with angina and myocardial infarct were done PCI(PTCA/PTCA percutaneous transcoronary angioplasty+stenting),the therapeutic efficacy was observed,and perioperative VEGF and CRP levels were determined.Results 146 brackets cases were placed in 127 cases,all brackets were successfully inserted into target vascular lesion sites;2 cases with two rami pathological changes given up PTCA because guide wire couldn’t pass anterior descending branch narrow part;4 cases took place no re-flow phenomenon,operation achievement ratio was 95.3%.The levels of post-operative CRP increased 142.9%,but the levels of post-operative VEGF decreased 31.9%.Conclusion The therapeutic efficacy PCI on coronary heart disease is satisfactory monitoring CRP and VEGF in blood serum could be helpful to understand the therapeutic efficacy and inflammation degree.更多还原