【摘要】 目的探讨孤立性纤维性肿瘤(solitaryfibroustumor,SFT)的临床病理特点及鉴别诊断。方法对3例SFT病例进行组织形态学及免疫组化分析并复习文献。结果肿瘤位于胸腔及腹腔,大小为11.0cm×9.5cm×8.0cm~10.0cm×10.5cm×7.2cm。镜下肿瘤组织由梭形纤维母细胞和不同程度的胶原纤维构成,呈束状或编织状排列,局部有血管外皮瘤样形态,部分区域黏液变性。免疫组化显示CD34、波形蛋白、bcl-2、CD99阳性,上皮和间皮等标记阴性。结论SFT是一种少见的梭形细胞肿瘤,组织形态与其他梭形细胞肿瘤相似,需结合免疫组化来进行诊断及鉴别诊断,CD34阳性具重要鉴别作用。更多还原

【Abstract】 Objective To study the clinicopathologic characteristics and differential diagnosis of the solitary fibrous tumor(SFT).Methods Three cases of solitary fibrous tumour were analyzed by histological observation and immunohistochemical techniques.Results The tumor located in thoracic cavity and abdomen cavity respectively with 11.0cm×9.5cm×8.0cm to 10.0cm×10.5cm×7.2cm in size.Histologically,the tumor was composed of fibroblastic like spindle cells and bands of hyalinized collagen in varying proportions,arranged in fascicles and storiform pattern and some parts stroma showed hemangiopericytoma-like pattern and myxoid changes.Immunohistochemically,the tumor cells were positively reacted with CD34,Ⅴ imentin,CD99 and bcl-2,but nagathvely with CK,calretinin,MG,EMA,Des,SMA,S-100 protin,CD68 and CD117 in three cases.Conclusion SFP is a rare spindle cell tumor,and can be dignosed by histological and immunohistochemical findings.更多还原