【摘要】 目的研究宫颈人乳头瘤病毒(HPV)感染与宫颈组织硒含量的关系。方法用第2代捕获杂交(HC2)法确定宫颈的HPV感染,再用基因分型检测系统确定其HPV亚型;荧光光度技术检测宫颈组织硒的含量。结果HPV感染组宫颈组织硒含量:118例慢性宫颈炎组为(5.33±2.32)mmol/g,宫颈上皮内瘤变(CIN)Ⅰ级组(83例)为(5.29±2.21)mmol/g,CINⅡ级组(44例)为(3.19±1.87)mmol/g,CINⅢ级组(31例)为(2.73±1.64)mmol/g。组间比较差异有显著性(P<0.05);278例HPV阴性对照宫颈组织硒的平均含量为(6.03±3.29)mmol/g,与HPV感染组比较差异有显著性(P<0.01)。结论硒含量与宫颈组织的HPV感染有关,其下降程度与病变程度相一致,补充适量的微量元素硒可能有利于CIN恢复。更多还原

【Abstract】 Objective To explore the relationship between cervical infection of human papilloma virus(HPV) and selenium content in cervical tissue.Methods To determine cervical infection of HPV with HC2 and their subgroups with gene typing system and the selenium content in cervical tissue with fluorospectro photometry.Results The average selenium content in cervical tissue of 118 cases with chronic cervicitis in 276 cases of HPV infection was(5.33±2.32) mmol/g,of 83 cases with cervical intraepithelial neoplasia(CIN)Ⅰ was(5.29±2.21) mmol/g,of 44 cases of CIN Ⅱ was(3.19±1.87) mmol/g,31 cases of CIN Ⅲ was(2.73±1.64) mmol/g,of 78 cases of negative control was (6.03±3.29) mmol/g.There seems to be a tendency that selenium content decreases by cervical affection aggravation and the selenium content in cervical tissue decreases in CIN Ⅲ was most obvious(P<0.01).Conclusion There is a relationship between selenium content decrease in cervical tissue and HPV infection and supplement of selenium may be beneficial to recovery from CIN.更多还原