Objective To study the histopathologic characteristics of the enlarged enhancement area of hepatocellular carcinoma (HCC) at contrast-enhanced ultrasound (CEUS) during the arterial or portal phase and evaluate the value of CEUS in identifying the invasion range of HCC.Methods Fifty-two patients with fifty-two lesions confirmed as HCC pathologically (41 by surgery and 11 by needle biopsy) were included. The lesion size, margin and shape at fundamental ultrasonography (US) and CEUS were compared before surger...