【摘要】 目的评价银杏酮酯(EGb₅₀)对大鼠坐骨神经损伤后神经再生的影响及其量效关系。方法建立大鼠坐骨神经损伤模型,将雄性SD大鼠96只随机分为4组：损伤对照组、银杏酮酯高剂量组(200mg·kg^-1·d^-1)、银杏酮酯中剂量组(100mg·kg^-1·d^-1)、银杏酮酯低剂量组(50mg·kg^-1·d^-1)。分别于术后2、4、6、8周用电生理学、组织学和功能测定评估坐骨神经再生和功能恢复情况。结果术后坐骨神经功能指数（SFI）、小腿三头肌肌张力、运动神经传导速度、小腿三头肌肌细胞截面积恢复率及有髓神经纤维通过率在各时间点上银杏酮酯各剂量组均优于对照组（P＜0．01）。除坐骨神经功能指数外,其它各项指标银杏酮酯高剂量组均优于中低剂量组（P＜0．01,P＜0．05）。结论银杏酮酯可以促进损伤神经的再生,且对神经再生的促进作用存在一定的量效关系。更多还原

【Abstract】 Objective To provide the promoting effect of extract of leave Ginkgo biloba(EGb₅₀)on nerve regeneration and the dose-effect relationship.Methods Sciatic nerve injury model was set up in 96 male Spraque-Daweiy rats and then randomly divided into four groups:normal saline （NS） group,the low dose EGb₅₀ group (50mg·kg^-1·d^-1),the moderate dose EGb₅₀ group (100 mg·kg^-1·d^-1) ,the high dose EGb₅₀ group (200 mg·kg^-1·d^-1).Electrophysiological,histological examinations and functional eval- uation were used to assess nerve regeneration and the functional recovery in 2,4,6,8 weeks of operative inter- vals respectively.Results The recovery rate of sciatic functional index（SFI）,tetanic tension,motor nerve conduction velocity,muscle cell cross-section area of triceps surae and the passing rate of myelinated nerve were significantly higher in EGb₅₀ group in all the time point than in control（P＜0.01）.Except the recovery rate of sciatic functional index （SFI）,there was significant difference between high dose group and moderate, low dose group.（P＜0.01,P＜0.05）.Conclusion EGb₅₀ has the effect of promoting regeneration of in- juried peripheral nerve and the high dose can get the best result.更多还原