【摘要】 目的探讨短期应用人类重组生长激素(rh-GH)对法洛四联症(TOF)病儿根治术后免疫功能的影响。方法30例TOF病儿分为常规组(20例)和rh-GH组(10例,rh-GH0·2U/kg,每周3次,皮下注射,连续应用4周);动态观察免疫球蛋白、补体、淋巴细胞表型和细胞因子的变化。结果应用rh-GH后,异常升高的IgG、IgM、C3、C4、CD8+和CD19+于治疗后第1~3周开始下降,异常下降的IgA、CD3+、CD4+、CD4+/CD8+、CD3+/HLA-DR+和CD3+/CD(16+56)于治疗后1~2周开始逐渐升高,且上述指标均于治疗后4周恢复到对照组水平。血浆和外周血单个核细胞体外产生的白细胞介素-6和肿瘤坏死因子-α于治疗后1~2周开始逐渐下降,于治疗后4周恢复到对照组水平。结论rh-GH可明显改善TOF病儿术后的免疫功能状态。更多还原

【Abstract】 Objective To explore the effects of recombinant human growth hormone（rh-GH） on immune function in children with tetralogy of Fallot （TOF） after radical operation. Methods Thirty children with TOF were divided into two groups: conventional （n=20） and rh-GH （n=10, 0.2U/kg rhGH, sc., three times per week for 4 weeks）. The immunoglobulin, complement fraction, lymphocyte subsets, and interleukins were determined. Results After treatment, the abnormal elevation of IgG, IgM, C₃, C₄, CD8⁺ and CD19⁺ in rhGH group decreased significantly at 1 week to 3 weeks; moreover, the abnormal descend of IgA, CD3⁺, CD4⁺, CD4⁺/CD8⁺, CD3⁺/HLA-DR⁺, and CD3⁺/CD （16+56） in rh-GH group increased significantly at 1 week to 2 weeks compared to those of conventional group; and all recovered to the levels of control at 4 weeks. The interleukin-6 and tumor necrosis factor-α levels in the plasma and supernatant of peripheral blood mononuclearcytes decreased gradually at 1 week to 2 weeks after treatment compared to those of conventional group, and also recovered to the levels of control at 4 weeks. Conclusion rh-GH therapy could significantly improve immune function of children with TOF after radical operation.更多还原