【摘要】 目的评价塞来昔布(西乐葆)对手外科手术后急性疼痛的疗效。方法将120名手外科手术患者按照随机双盲方法分为A、B、C组,每组40名。3组分别为安慰剂组、塞来昔布术后镇痛组、塞来昔布先发镇痛组。记录并评估塞来昔布的手术后镇痛效果。结果A组与B组、C组相比,疼痛的可视模拟测量仪(visual analog scale,VAS)值的差异有统计学意义(P＜0．01)。B组与C组相比VAS值的差异无统计学意义(P＞0．05),但在术后第1天B、C组相比VAS值的差异有统计学意义(P＜0．01)。盲底：A组为安慰剂组,B组为塞来昔布术后镇痛组,C组为塞来昔布先发镇痛组。结论塞来昔布对手外科手术后轻中度疼痛有明显的镇痛作用,术前服用一定剂量的塞来昔布可以得到先发镇痛的效果。短期服用正常剂量的塞来昔布是安全的、耐受性良好。更多还原

【Abstract】 Objective To evaluate the efficacy of celecoxib in the treatment of acute pain after hand surgery.Methods In this double-blinded,randomized parallel-group trial,120 adult patients were divided into three groups.Group A received placebo for 5 days.Group B were given celecoxib after surgery for 5 days. Group C received an additional dose celecoxib preoperatively.Visual analog scale was used to evaluate postoperative pain.Results Compared with placebo,celecoxib significantly reduced postoperative pain (P＜0.01).When the additional celecoxib before surgery group was compared with the celecoxib after surgery group, significant pain relief was noticed in the first day after the surgery(P＜0.01).Conclusion Celecoxib was useful in the control of mild to moderate pain after hand surgery.Additional dose celecoxib administered before surgery was effective in reducing pain at postoperative day one.The application of short-term,normal dose celecoxib was safe and well tolerated.更多还原