【摘要】 目的检测和对比数年来泌尿生殖道沙眼衣原体（Ct）临床分离株对几种常用抗菌药物的敏感性。方法分别选用1997年、1999年、2001年、2003年和2005年临床泌尿生殖道Ct分离株,用McCoy细胞培养法鉴定,检测7种药物抗Ct体外抗菌活性,测定其最小抑菌浓度（MIC）和最小杀菌浓度（MBC）。结果1997-2005年,几种常用药物MIC₉₀、MBC₉₀均有不同程度升高,尤其是左氧氟沙星升高最为明显,MIC₉₀由0．063 mg/L升高至1 mg/L,MBC₉₀由0．063 mg/L升高至4 mg/L,2005年Ct临床分离株,克拉霉素、司帕沙星和莫西沙星杀菌浓度均较低,其MBC₉₀分别为：0．25 mg/L、0．125 mg/L和0．063 mg/L。结论Ct对几种常用抗菌药物的体外敏感性降低；目前Ct临床分离株对克拉霉素、司帕沙星和新药莫西沙星有较好敏感性。更多还原

【Abstract】 Objective To detect and compare the in vitro activities of several antimicrobial agents against isolates of Chlamydia trachomatis （Ct） cultured from the genitalia in the past several years.Meth- ods Strains of Ct cultured in 1997,1999,2001,2003 and 2005 were selected.The minimal inhibitory con- centration （MIC） and minimal bactericidal concentration （MBC） of 7 antibacterial agents,including ery- thromycin,minocycline,azithromycin,clarithromycin,levo-ofloxacin,sparfloxacin and moxifloxacin,against these strains were assessed in McCoy cell culture.Results The MIC₉₀ and MBC₉₀ of the these drugs in- creased from 1997 to 2005,especially those of levofloxacin,which increased from 0.063 mg/L to 1 mg/L and from 0.063 mg/L to 4 mg/L,respectively.The MIC₉₀ and MBC₉₀ of clarithromycin,sparfloxacin and moxifloxacin against clinical isolates of Ct in 2005 were relatively low,with the MBC₉₀ of 0.25 mg/L,0.125 mg/L and 0.063 mg/L respectively.Conclusions In the past several years,the in vitro effectiveness of these antimicrobial agents against clinical Ct isolates have gradually decreased;clarithromycin,sparfloxacin and moxifloxacin showed good in vitro activity against the most recent isolates of genital Ct.更多还原