【摘要】 考察了不同浓度泊洛沙姆407、PEG 6000和泊洛沙姆188及处方最利巴韦林对鼻用温敏凝胶的热力学[胶凝温度（T₁）、胶融温度（T₂）]和流变学性质（黏度）的影响。结果表明,凝胶的T₁和黏度均与泊洛沙姆407浓度呈负相关,而T₂则与其呈正相关；利巴韦林和相应辅料对凝胶的T₁、T₂和黏度都有不同程度的影响。更多还原

【Abstract】 Effects of different concentrations of Poloxamer 407,PEG 6000 and Poloxamer 188 and formulated amount of ribavirin on thermodynamic[gelation（T₁）and gel melting（T₂）]and rheological（viscosity）properties of nasal thermosensitive gels were investigated.The results showed there was a negative correlation between T₁,viscosity and Poloxamer 407concentration.A positive correlation was founded between T₂ and Poloxamer 407 concentration.The other two excipients and ribavirin had different degrees of effects on T₁,T₂ and viscosity.更多还原