【摘要】 庚二酸经双酯化后歧化为其单酯,经酰氯化、付-克反应、还原、水解得7-羟基-7-苯基庚酸,再与三甲基氢醌缩合、氧化制得抗哮喘药塞曲司特,总收率接近40％。更多还原

【Abstract】 Seratrodast was synthesized from pimelic acid via 7-hydroxy-7-phenylheptanoic acid, which underwent condensation with trimethylhydroquinone and then oxidation with an overall yield of 40%.更多还原