【摘要】 对硝基苯硫酚经甲基化、氯化、氟代、还原、重氮化及水解制得4-三氟甲硫基苯酚,与3-甲基-4-氯硝基苯缩合、还原、异氰酸酯化后再与甲基脲反应、环合制得抗球虫药托曲珠利,总收率接近19%。更多还原

【Abstract】 Toltrazuril was synthesized from 4-nitrothiophenol via methylation, chlorination, fluorination, reduction, diazotization and hydrolysis to give 4-(trifluoromethylthio)phenol, which subjected to reduction, isocyanation and then condensation with methylurea followed by cyclization with an overall yield of 19%.更多还原