【摘要】 比较了用模型拟合法和直接比较法(差异因子法和相似因子法)拟合不同处方硫酸沙丁胺醇脉冲微丸体外释放行为的情况。两种方法的拟合结果均表明3种处方微丸的体外释放结果有显著差异。在各数学模型中logistic的拟合效果最好。更多还原

【Abstract】 The in vitro dissolution profiles of salbutamol pulsatile pellets were fitted and compared by model fittingand model independent methods (difference factor method and similarity factor method). The results of both methodsshowed that the in vitro release of three formulations of salbutamol pulsatile release pellets had significant difference. Thelogistic model was the best one for fitting the dissolution profiles in the several mathematical models.更多还原