【摘要】 目的探讨膝骨关节炎(OA)的相关危险因素,以提高膝OA的预防水平。方法参照亚太地区风湿病学会联合会社区控制风湿病规划《膝OA危险因素调查表》(草案),对太原市某社区2188名居住无电梯6层楼房10年以上的35～64岁居民进行调查。采用logistic回归分析,观察性别、年龄、体重指数、腰围、工龄、受教育程度、吸烟、宗教信仰等因素对膝OA的影响。结果太原市居民膝痛和膝OA患病率分别为13．6％和10．9％,显著高于南方城市汕头,OA患病率与北方城市北京相近;女性患病率显著高于男性(18．3％比8．7％和15．1％比6．3％),且有随年龄增加而升高的趋势。膝OA患病率在女性40岁以后、男性45岁以后升高更为显著。膝OA组体重指数显著大于非膝OA组。多因素logistic回归分析结果显示:年龄、性别、体重指数为膝OA的危险因素。不同楼层膝痛和膝OA患病率差异无统计学意义。结论地理位置、年龄、女性和超重(体重指数≥24 kg／m2)可能是膝OA的相关危险因素,未发现爬楼梯与膝OA有关联。中年人(尤其是女性)即应开始预防膝OA;控制体重、防止肥胖对预防膝OA有重要意义。更多还原

【Abstract】 Objective Osteoarthritis (OA) of the knee is found to be one of the commonest rheumatic disorders. For prevention of knee OA, the risk factors for this condition should first be identified. Methods A population sample of 2188 adults aged 35-64 years, living in 6-storey buildings without elevators, was surveyed from April to August 2005 in the urban of Taiyuan region, north China. Protocol of APLAR-COPCORD Core Questionnaire for identification of risk factors for knee OA was implemented. The positive respondents were examined simultaneously by rheumatologists. Lateral and anterior-posterior non-weight-bearing knee radiographs were arranged. Variables such as sex, age, body mass index (BMI) , waist circumference, education level, and smoking et al, were included in binary logistic regression model for further analysis. Results Prevalence rate of knee pain and knee OA was 13.6% and 10. 9% respectively, significantly higher than that in Shantou - in south of China and similar with Beijing - in north of China. Both of these prevalence was significantly higher in women than that in men (18. 3% vs. 8. 7% and 15. 1% vs. 6. 3% ), and with a tendency of being increased with age. The prevalence rate of knee OA was increased more obviously in people after 40 years old in women and after 45 years old in men. BMI in knee OA group was significantly higher than that in non- knee OA group. Binary logistic regression revealed that age, sex, and BMI were significantly associated with knee OA. Whereas there were no significant association between the other factors such as climbing stairs, waist circumference, time length of occupation service, education level, smoking, as well as religious belief and knee OA. Conclusions Geography, aging (aged >40 years in woman and >45 years in man, respectively) , female, and overweight (BMI≥24 kg/m2) might be the associated risk factors of knee OA. No association between climbing stairs and knee OA was found. Prevention of knee OA should be initiated before the middle-aged, especially in female. Controlling body weight and avoiding obesity are important in preventing knee OA.更多还原