【摘要】 用免疫组化检测甲状腺良恶性肿瘤组织中肝细胞生长因子(HGF)及其受体(c-Met)的表达。结果显示HGF和c-Met蛋白阳性表达率在腺癌组中显著高于腺瘤组,尤其滤泡性腺癌组显著高于滤泡性腺瘤组,二者表达强度在乳头状腺癌组呈显著正相关。提示HGF和c-Met的异常表达可能对甲状腺良恶性肿瘤的鉴别诊断、预后判断有一定参考意义。更多还原

【Abstract】 The expressions of hepatocyte growth factor (HGF) and its receptor (c-Met) protein were examined by immunohistochemistry in benign and malignant thyroid neoplasms.The results showed that the positive rates of HGF and c-Met protein expressions in thyroid carcinomas were significantly higher than those of thyroid adenomas,and especially the expressions of HGF and c-Met proteins in follicular thyroid carcinomas were significantly higher than those in follicular thyroid adenomas.There existed significantly positive correlation between the expression degrees of HGF and c-Met in follicular thyroid carcinoma.Thus,the expressions of HGF and c-Met may be valuable in predicting prognosis of thyroid carcinomas and differentiating benign from malignant thyroid neoplasms.更多还原