【摘要】 目的观察妊娠对大鼠吸入性全麻药血／气分配系数及组织／气分配系数的影响。方法健康成年(3月龄)雌性妊娠(妊娠18-22 d)和非妊娠SD大鼠各10只,分别为妊娠组和非妊娠组。腹腔注射戊巴比妥钠40mg/kg麻醉,经腹主动脉抽血用于测血／气分配系数,放血处死后,分别取心、肝、肾及脑组织并制成匀浆,采用注射器顶空二次平衡法经气相色谱仪测定七氟醚、异氟醚和氟烷的血／气分配系数及组织／气分配系数。结果与非妊娠组相比,妊娠组氟烷的血/气分配系数和脑／气分配系数降低(P<0．05),七氟醚、异氟醚的血/气分配系数、肝／气分配系数、肾／气分配系数、心／气分配系数差异无统计学意义(P>0．05)。结论妊娠降低大鼠氟烷的血／气配系数和脑／气分配系数,但不影响七氟醚和异氟醚的血／气分配系数和组织/气分配系数。更多还原

【Abstract】 Objective To determine blood/gas and tissue/gas partition coefficients of sevoflurane, isoflurane and halothane and evaluate the effects of pregnancy on them. Methods Ten 18-22 day pregnant and 10 non-pregnant SD rats were killed under pentobarbital anesthesia. The tissue specimens of heart, liver, kidney and brain were obtained and made into homogenates respectively. The blood/gas and tissue/gas partition coefficients of sevoflurane, isoflurane and halothane were determined using a method of 2-stage headspace equilibration by gas chromatography. Results Blood/gas and brain/gas partition coefficients were lower in pregnant group than in non-pregnant group (P<0.05) ,but there were no significant differences in other tissue/gas partition coefficients of halothane between the two groups. There were also no significant differences in blood/gas and tissue/gas partition coefficients of sevoflurane and isoflurane between the two groups. Conclusion Pregnancy decreases blood/gas and brain/gas partition coefficients of halothane whereas there were no significant differences in other tissue/gas partition coefficient of halothane between the two groups. Pregnancy does not affect blood/gas and tissue/gas partition coefficients of sevoflurane and isoflurane.更多还原