【摘要】 目的探讨出生缺陷高发地区出生缺陷与相关社会经济危险因素的关系。方法在山西省吕梁地区中阳、交口、柳林三县对生育出生缺陷儿的母亲和对照组分别进行社会经济因素与出生缺陷关系的问卷调查,调查共回收问卷519份,有效问卷491份,有效率94．6%。利用logistic回归分析了影响当地出生缺陷高发的社会经济危险因素。结果多因素logistic回归模型中,家庭经济状况、优生优育知识、行为因素、母亲孕早期患病等与是否生育出生缺陷儿关系显著(P值分别为0．000、0．001、0．005和0．012),OR值(95%CI)依次为0．535(0．383～0．748)、3．265(1．664～6．405)、0．403 (0．213～0．762)和1．379(1．072～1．774)。家庭经济状况越好,妇女掌握的优生优育知识越多,生育出生缺陷儿的风险越低；而父亲饮酒、母亲孕早期患病与出生缺陷发生高度正相关。结论提高育龄妇女认知水平,改变不良生活方式,改善育龄妇女健康状况,对于降低出生缺陷发生风险尤为重要。更多还原

【Abstract】 Objective To study the risk factors in high prevalence district of birth defects(BD) to provide evidence for intervention development.Methods Quantitative analysis had been carried out based on the investigation at three counties in Shanxi province.491 useable questionnaires had been collected with a response rate as 94.6%.Binary logistic regression was performed to analyze the risk factors of BD. Results Data from logistic regression analyses revealed that factors as:the status of family income, knowledge on healthy birth and rearing,behavior and illness during pregnancy were influencing the occurrence of BD,with OR values as 0.535,3.265,0.403 and 1.379 respectively.Better family income and knowledge on BD were negatively (P values are 0.000 and 0.001 respectively),while illness during pregnancy and alcohol intake of the husbands were positively correlated (P values are 0.005 and 0.012 respectively) to the occurrence of BD.Conclusion Measures as accelerating the development of local economy,providing education on BD knowledge to the couples,changing negative life style and improving the health status would reduce the risk of BD.Preconceptional-periconceptional care seemed to be the new idea for healthy pregnancy and healthy baby.更多还原