【摘要】 目的调查四川省某地区静脉吸毒人群艾滋病病毒(HIV)和梅毒血清抗体阳转情况及其危险因素。方法 2002年11月在四川省西昌市以社区为基础招募HIV血清抗体阴性的静脉吸毒人群前瞻性研究队列333人,在队列每6个月随访时调查静脉吸毒人群高危吸毒行为和性行为情况, 并采集血样进行HIV和梅毒抗体检测。结果队列随访2年,静脉吸毒人群队列保持率和HIV血清抗体阳转率分别为75．7％和2．53／100人年(95％CI:1．10-3．97),在多因素Poisson回归模型分析中,民族(RR=12．42,95％CI:2．72-56．74,P=0．0012)、近3个月共用针头或注射器(RR=4．06, 95％CI:1．29-12．81,P=0．0168)与HIV血清抗体阳转的关系有统计学意义。该研究队列梅毒血清抗体阳转率为4．71/100人年(95％CI:2．59-6．82),在多因素Poisson回归模型中,女性(RR= 4．42,95％CI:1．78-10．99,P=0．0014)与梅毒血清抗体阳转的关系有统计学意义。结论该地区静脉吸毒人群HIV和梅毒新发感染率高,应采取有效的干预措施以控制HIV的传播流行。更多还原

【Abstract】 Objective To study the rate of human immunodeficiency virus(HIV) seroconversion, HIV transmission and related risk factors among injecting drug users(IDUs) in an area of Sichuan province. Methods In November 2002, a community-based baseline survey was conducted to recruit 333 HIV-seronegative IDUs for a prospective cohort study in Xichang county of Sichuan province, China. Follow-up visits were carried out every 6 months to study the situation of drug use, sexual behaviors of the IDUs and blood specimens were collected to test for antibodies against HIV and syphilis. Results During a 24-month follow-up period, cohort retention rate and HIV incidence were 75.7% and 2.53 per 100 person-years [95% confidence interval(CI) : 1.10-3.97)], respectively. Multivariate Poisson regression model showed that risk factors which were significantly associated with HIV seroconversion would include: ethnicity (RR=12.42; 95%CI: 2.72-56.74, P=0.0012) and needle or syringe sharing in the past 3 months (RR=4.06; 95%CI: 1. 29-12.81 ,P = 0.0168). Syphilis seroconversion in this cohort was 4.71 per 100 person-years (95% CI:2. 59-6.82). In multivariate Poisson regression being female (RR = 4.42; 95% CI:l.78-10.99, P= 0.0014) appeared to be the only factor which was significantly associated with syphilis seroconversion. Conclusion Our study results showed that there was a rapid transmission of HIV and syphilis among IDUs in Sichuan province, suggesting that effective intervention should be urgently taken.更多还原