【摘要】 目的分析基质金属蛋白酶(MMP)2,膜型基质金属蛋白酶1(MT1-MMP),基质金属蛋白酶抑制剂(TIMP)2在口腔扁平苔藓(OLP)中的表达及意义。方法通过免疫组化检测其在OLP中的表达并与口腔鳞状细胞癌(OSCC)及正常口腔黏膜进行比较。结果从正常口腔黏膜(NOM)、非萎缩型OLP,到萎缩型OLP和OSCC 3种酶表达依次增加。萎缩型OLP中MMP-2和MT1-MMP的表达明显高于NOM和非萎缩型OLP,与OSCC表达相似。TIMP-2的表达亦随着MMP的增高而增加,但与MMP-2和MT1-MMP相比,其增加量相对较低。结论MMP表达的高低可能成为判断OLP恶变潜能的检测指标之一。更多还原

【Abstract】 Objective To investigate the role of MMP-2, MT1-MMP and TIMP-2 in the carcinogenesis of oral lichen planus (OLP). Methods Immunohistochemistry was performed to examine the expression of OLP and compare with that of NOM. Results The expression of these proteinases significantly increased from NOM, non-atrophic OLP, to atrophic OLP and OSCC. The expression of MMP-2 and MT1-MMP in atrophic OLP was significantly higher than in non-atropic OLP. Furthermore, the expression of TIMP-2 consequently increased with the increasing of the MMP, but the increase of TIMP-2 was less than that of MMP. Conclusions MMP may be useful marker to judge the possibility of malignant change of OLP.更多还原