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Measurement and Correlation for Solubility of (S)-(+)-2,2-Dimethyl-cyclopropane Carbox Amide in Different Solvents

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【Author】 SHI Xiaohua a,b, ZHOU Cairong b, GAO Yuguo b and CHEN Xin-zhi a,* a College of Materials Science and Chemical Engineering, Zhejiang University, Hangzhou 310027, China b College of Chemical Engineering, Zhengzhou University, Zhengzhou 450002, China

【机构】 College of Materials Science and Chemical Engineering Zhejiang University Hangzhou 310027 China College of Chemical Engineering Zhengzhou University Zhengzhou 450002 China； College of Chemical Engineering Zhengzhou University Zhengzhou 450002 China； College of Materials Science and Chemical Engineering Zhejiang University Hangzhou 310027 China；

【Abstract】 (S)-(+)-2,2-dimethylcyclopropane carbox amide is a key intermediate of Cilastatin, an inhibitor of de- hydropeptidase-I. Its corresponding solid-liquid equilibrium data will provide essential support for industrial design and further theoretical studies. The solubilities of (S)-(+)-2,2-dimethylcyclopropane carbox amide in toluene, di- chloromethane, trichloromethane, ethyl acetate, ethanol and pure water at different temperature were measured us- ing the synthetic method by a laser monitoring observation technique. The solubility data were correlated with the modified Apelblat equation. The calculated values were good in agreement with the experimental values.更多还原

【关键词】 solid-liquid equilibrium； solubility； (S)-(+)-2； 2-dimethylcyclopropane carbox amide；
【Key words】 solid-liquid equilibrium； solubility； (S)-(+)-2； 2-dimethylcyclopropane carbox amide；

【文献出处】 Chinese Journal of Chemical Engineering ,中国化学工程学报(英文版) , 编辑部邮箱 ,2006年04期

【分类号】O621.25
【被引频次】13
【下载频次】80

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