【摘要】 目的探讨70岁以上高龄非小细胞肺癌患者的合理放疗方案。方法对39例70岁以上非小细胞肺癌患者实施了三维适形放疗(3DCRT)。患者年龄70~87岁,中位年龄79岁。全组卡氏评分20例50~60,19例≥70。3DCRT处方剂量为40~60 Gy,中位剂量为50 Gy。结果36例在治疗结束时临床症状获得改善,3例无变化。全组生存时间为3~50个月,中位生存时间为10个月。肿瘤获得完全缓解19例,部分缓解17例。1年生存率为60%。结论90%以上获得临床症状缓解,生活质量得到改善。对70岁以上癌症患者应予以老年病学方面的评价、分组后酌情采取治疗措施,将治疗益处最大化,将治疗危险最小化。更多还原

【Abstract】 Objective To study the role of three-dimensional conformal radiation therapy(3DCRT) in the treatment of elderly non-small cell lung cancer(NSCLC) patients.Methods From 2000 to 2004,39 elderly NSCLC patients(range 70-87 years) were treated by 3DCRT.Their Karnovsky performance score was 50-60 in 20 patients and those of the other 19 patients were not less than 70.Prescription dose were 40-60?Gy,with a median of 50?Gy.Results Thirty-six(92%) patients’symptoms were relieved at the end of treatment,with the other three patients’ symptoms steady.Complete response and partial response was achieved in 19 and 17 patients respectively.The 1-year survival rate was 60%,with a median survival time of 10 months.Conclusions Three dimensional conformal radiotherapy is effective for elderly NSCLC patients in terms of symptom relief.For treatment choice of these senior NSCLC patients,the balance between tumor control and quality of life should be carefully considered.更多还原