【摘要】 目的观察三维适形放疗联合TACE对不能手术的原发性肝癌伴门静脉癌栓的临床疗效。方法33例原发性肝癌合并门静脉癌栓患者,TACE1~2次后,行三维适形放射治疗,大体肿瘤靶区只包括癌栓,不包括肝内原发灶,采用4~6个共面或非共面照射野,使90%的等剂量曲线覆盖PTV。照射总量45~60Gy,单次照射剂量2~4Gy/次。结果有效率(CR+PR)为54·6%(18/33),1、2年的生存率分别为45·5%和21·2%。无严重并发症出现。结论三维适形放射治疗联合TACE对肝癌合并门静脉癌栓有较好的疗效。更多还原

【Abstract】 Objective To study clinical therapeutic effctiveness of combined 3-dimensional conformal radiotherapy(3DCRT)and transcatheter arterial chemoembolization for portal vein tumor thrombus(PVTT)in unresectable hepatocellular carcinoma(HCC). Methods 33 patients with unresectable hepatocellular carcinoma complicated with tumor thrombus in the portal vein were enroled in this study. RT was started 1-2 fractions following TACE. A total dose of 45-60 Gy was given as daily 2-4 Gy fractions, with the gross tumor volume(GTV) defined as only PVTT, 90% isodose line covering PTV. Results The effective rate was 54.6%. Survival rates at year 1 and 2 were 45.5% and 21.2%, respectively. Conclusions 3DCRT combined with TACE is an effective method in the treatment of portal vein tumor thrombus in unresectable hepatocellular carcinoma.;更多还原