【摘要】 目的观察短时间快速心房起搏对犬左、右心房大小及收缩功能的影响。方法健康杂种犬12只犬,经股静脉将起搏电极插入犬右心耳,起搏频率为450次/min,持续5h后,应用声学定量技术记录12只犬起搏前及起搏后(均为窦性心律)的左右心房容量-时间曲线,并计算相关指标。结果持续快速刺激5h后,左、右心房体积明显增加;左房收缩末期容积从(5.921±1.51)ml到(7.27±1.86)ml,右房收缩末期容积从(3.12±0.71)ml到(3.58±0.73)ml。而左、右心房收缩功能明显下降,左房射血分数从(51.03±9.45)%降至(38.23±10.52)%,右房射血分数从(36.76±5.36)%降至(30.71±7.97)%。其中左房收缩末期容积增加23%,右房收缩末期容积增加8%,两者改变的差异有统计学意义(P<0.01);左房射血分数降低23%,右房射血分数降低6%,两者改变的差异有统计学意义(P<0.05)。结论短时间快速心房电活动即可使左、右心房扩大,心房收缩功能明显下降,但主要影响左房,对右房大小及功能影响相对略小。更多还原

【Abstract】 Objective To observe short-term rapid atrial electrical activation on atrial size and atrial systolic function. Methods Twelve anesthetized mongrel dogs were underwent insertion of a transvenous lead at the right atrial appendage and subjected to 5 hours of rapid right atrial pacing at 450 beat/min. Acoustic quantification(AQ) waveform on biatrial was recorded before and after 5 hours pacing with AQ technique. All measurements were made in sinus rhythm. Results After 5 hours rapid right atrial pacing, end systolic volume(ESV) of both left and right atrial enlarged significantly from ( 5.92 ± 1.51 )ml to ( 7.27 ± 1.86 )ml,from ( 3.13± 0.71 )ml to ( 3.58 ± 0.73 )ml, respectively; but biatrial function decreased markedly,left and right atrial ejection fraction decreased from ( 51.03 ± 9.45 ) to ( 38.23 ± 10.52 ),from ( 36.76 ± 5.36 ) to ( 30.71 ± 7.97 ), respectively. However, left atrial ESV enlarged more than right atrial (by 23 vs 8,P< 0.01 ); and the function of left atrial decreased more than that of right atrial (by 23 vs 6,P< 0.05 ). Conclusions Even after short-term rapid atrial pacing, biatrial function are impaired while their sizes are enlarged. But compared with left atrial, pacing has less effect on size and systolic function of right atrial.更多还原