【摘要】 目的:优化蟾酥固体脂质纳米粒的制备工艺。方法:以冷却-匀质法制备固体脂质纳米粒,以平均粒径、包封率、载药量及总评“归一值”为评价指标,采用星点设计考察辅料山榆酸甘油酯用量、注射用大豆磷脂用量、泊洛沙姆188用量3因素对制备工艺的影响,对结果进行多元线性和二项式拟合,效应面法选取最佳工艺条件进行预测分析。结果:从复相关系数上看,各指标二项式拟合方程均优于多元线性回归方程,根据优化工艺制得蟾酥固体脂质纳米粒的平均粒径为71.5 nm,包封率为92.45%,载药量为5.26%。结论:优选的蟾酥固体脂质纳米粒制备工艺稳定可行,包封率高,可用于生产。更多还原

【Abstract】 Objective: To optimize the formulation of chansu-loaded solid lipid nanoparticles(Cs-SLN).Method: Cs-SLN was prepared by cold homogenization technique. The effects of influence factors such as the weight of compritol 888 ATO,soybean lecithin and poloxamer 188,on mean diameter,entrapment efficiency,drug loading and overall desirability were investigated by using central composite design and response surface method.The data were imitated using multi-linear equation and second-order polynomial equation.Result: The latter was prior to the former considering from multiple correlation coefficients.Under the optimal conditions,the mean diameter,entrapment efficiency,drug loading of the Cs-SLN were 71.5 nm,92.45% and 5.26%.Conclusion: The optimized preparation technique for Cs-SLN is stable,feasible and high inclusion rate.It can be used for production of Cs-SLN.更多还原