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代谢组学在中医药复杂理论体系研究中的应用

Application of metabonomics in complicated theory system research of traditional Chinese medicine

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【作者】 贾伟蒋健刘平赵立平陈闽军周明眉杨丽萍王米渠邱明丰张永煜

【Author】 JIA Wei~1,LIU Ping~2,JIANG Jian~2,CHEN Min-jun~1,ZHAO Li-ping~1,ZHOU Ming-mei~2,YANG Li-ping~3,WANG Mi-qu~3,QIU Mingfeng~1,ZHANG Yong-yu~2(1.Shanghai Institute for System Biology,Shanghai Jiao Tong University,Shanghai 200030,China;2.Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China3.Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)

【机构】 上海交通大学上海系统生物学研究所上海中医药大学成都中医药大学上海中医药大学 上海200030上海201203上海200030四川成都610075

【摘要】 新兴学科代谢组学的出现,给中医药复杂理论体系的研究、中医药现代化提供了强有力的研究手段。中医病证引起代谢物组的共性分析和生物标记物的发现,可促进“证”本质的研究、中医辨证的科学化和定量化,深层次理解中医脏象理论,预测疾病的发生,整体性评价中药复方综合疗效、安全性和作用机制,反应肠道内生态环境状况。代谢组学和中医药学的结合,将探索出中医药复杂理论体系研究的新方法与新途径。

【Abstract】 Metabonomics,a new and rapid-developing technology,will be powerful means to the research of complexed theory system and modernization of traditional Chinese medicine(TCM).Discovery of biomarkers and analysis of common properties from the metabolome of a specific TCM syndrome will facilitate the modernized study of TCM system,promote the quantitative and scientific elucidation of TCM syndrome differentiation,provide an in-depth understanding of the TCM theory of Zang-xiang,help predict the disease on-set,and achieve a comprehensive evaluation of systemic clinical efficacy,safety and mechanism of action of the TCM combination formulas along with a better understanding of intestinal microflora ecology.The new approach with combined metabonomics and TCM methodologies will provide a new pathway and methodology for the study of complicated theory system of TCM and its modernization.

  • 【文献出处】 中国中药杂志 ,China Journal of Chinese Materia Medica , 编辑部邮箱 ,2006年08期
  • 【分类号】R2-03
  • 【被引频次】346
  • 【下载频次】4402
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