【摘要】 目的:研究黄瑞香Daphne giraldii茎皮(即祖师麻)的镇痛活性成分。方法:在药理活性跟踪下进行植物乙醇提取物的萃取、色谱分离,利用核磁、质谱等鉴定化合物结构。结果:从具有强镇痛活性的提取物中分离得到了4个化合物,其中3个被鉴定为二萜原酸酯类化合物gniditrin(1),gnidicin(2)和瑞香毒素(daphnetoxin,3),4被鉴定为Z-咖啡酸硬脂醇酯。结论:化合物1,2和4均为首次从该种植物中分离得到。更多还原

【Abstract】 Objective: To study the constituents with the pain-relieving activity from the stem rind of Daphne giraldii.Method: The partition of the ethanol extract and chromatographic separation of the fractions were carried out by the monitoring of anelgesic pharmacological activity.The structures of the isolated compounds were determined by MS and NMR.Result: Four compounds were isolated from the pain-relieving fraction.Three of them were identified as diterpenes,gniditrin(1),gnidicin(2) and daphnetoxin(3).Compound 4 was determined as Z-octadecyl caffeate.Conclusion: Compounds 1,2 and 4 were isolated from the plant for the first time.更多还原