【摘要】 目的:研究白英乙醇提取物体内外抗肿瘤作用。方法:采用MTT法观察白英乙醇提取物体外对人肝癌BEL-7402细胞及人胃腺癌SGC-7901细胞的增殖抑制作用;以小鼠S180肉瘤及H22肝癌为模型,观察白英乙醇提取物在体内对肿瘤生长的抑制作用。结果:白英乙醇提取物对人肝癌BEL-7402细胞及人胃腺癌SGC-7901细胞有增殖抑制作用,且均呈现良好的浓度-效应依赖关系,作用48 h的IC50值分别为(287.40±5.84),(176.14±5.18)μg.mL-1;白英乙醇提取物在体内对小鼠S180肉瘤和H22肝癌肿瘤的生长均有显著的抑制作用,且呈现良好的剂量-效应关系,高剂量组的抑瘤率分别达到(41.15±4.54)%和(45.00±7.37)%。结论:白英乙醇提取物具有抗肿瘤作用。更多还原

【Abstract】 Objective: To observe the anti-tumor activity of the ethanol extracts of Solanum lyratum in vitro and in vivo.Method: In vitro,the inhibitory effects of ethanol extracts of S.lyratum on proliferation of human hepatoma BEL-7402 cell and gastric carcinoma SGC-7901 cell were measured by MTT colorimetric assay.The mouse tumor model was used to investigate the effects of ethanol extracts on tumor growth.Result: The studies demonstrated that ethanol extracts of S.lyratum inhibited proliferation of BEL-7402 cells and SGC-7901 cells,and the IC₅₀values on them were（287.40±5.84） μg·mL^-1 and（176.14±5.18） μg·mL^-1,respectively.The tumor inhibitory rate of high doses of ethanol extracts on S180 sarcoma-transplanted mice and H22 hepatic cancer were（41.15±4.54）% and（45.00±7.37）%,respectively.When the dose of ethanol extracts varied from low to high,it was able to inhibit the growth of S180 sarcomatransplanted mice and H22 hepatic cancer in a dose-dependent manner.Conclusion: In tumor inhibitory test,it was shown that the ethanol extracts of S.lyratum may possess significantly inhibitory effect in vitro and in vivo.No acute toxic effect was found in our experiment.更多还原