【摘要】 目的:研究茅莓总皂苷(TGRP)对局灶性脑缺血的保护作用。方法:采用大脑中动脉阻塞(MACO)法制备大鼠局灶性脑缺血模型;脑梗死区重量用TTC染色法测定,超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)及细胞凋亡均采用测试药盒测定。结果:TGRP 10,20 mg.kg-1可改善大鼠异常神经症状,使MACO大鼠的SOD,GSH-Px活力提高,MDA生成减少,减少脑皮层细胞凋亡数。结论:TGRP对脑梗死有保护作用,其作用机制可能与抗自由基、抑制细胞凋亡有关。更多还原

【Abstract】 Objective: To observe the protective effects of total glycosides Rubus parviflolius（TGRP） on local cerebral ischemic.Method: The local cerebral ischemia in rat was made by middle cerebral artery occlusion（MACO）.The infraction weight was determined by TTC stain. SOD,MDA,GSH and apoptotis were determined with different method respectively.Result: TGRP 20,10 mg·kg^-1ig markedly improved the abnormal nervous symptoms,incredsed the SOD,GSH activity and reduced contentes of MDA in brain of MACO rat,TGRP 20 mg·kg^-1 ig significantly decreased the numbers of apoptotic cells in ischemic cortex.Conclusion: TGRP has protective effects against cerebral infrction,and its mechanism may be related to anti-apoptotis and free radical.更多还原