【摘要】 目的:探讨血脂水平与胆道癌、胆石症的关系。方法:采用全人群病例对照研究方法,对上海市区462例胆道癌、982例胆石症和808例人群对照进行六项血脂指标的检测,采用多样本比较的秩和检验方法分析血脂水平与胆道癌和胆石症的关系。结果:男性胆石症层中,胆道癌患者TG的含量高于胆石症患者和人群对照;且各部位胆石症和胆道癌患者HDL的含量均低于人群对照。男性非胆石症层中,胆道癌患者TG和ApoB的含量显著高于人群对照,而TC、HDL、LDL和ApoA的水平则低于人群对照。在女性胆石症层中,胆道癌、胆石症患者和人群对照HDL、ApoA的平均含量由高到低分别为人群对照、胆石症和胆道癌患者。女性非胆石症层中,胆道癌患者HDL和ApoA的平均含量均显著低于人群对照。结论:男女性胆道癌和胆石症患者都存在脂质代谢异常,胆道癌患者TG水平高于对照和胆石症患者,而HDL水平则低于对照和胆石症患者。更多还原

【Abstract】 Objective: To investigate the levels of plasma lipids in patients with bile-tract cancer and cholelithiasis and to study the relationship between them. Methods: A population-based case-control study was conducted in urban Shanghai. Six indices of serum lipids were assayed in 462 new cases of biliary tract cancers, 982 patients with cholelithiasis and 808 healthy subjects. Non-parametric statistical method (Kruskal-Wallis rank sum test) was used to analyze and compare the level of serum lipids among patients with biliary tract cancer, gallstones and the normal controls. Results: Among male patients with gallstones, the concentration of triglycerides (TG) in biliary tract cancer patients was higher than that in cholelithiasis patients and the normal controls. The levels of HDL were statistically different among biliary tract cancer, cholelithiasis patients and the normal controls. Moreover, the levels of HDL were lower among the cases of all three sites of biliary tract cancers and gallstone disease patients than those in the normal controls. Among male subjects without gallstones, the concentrations of TG and ApoB in the group with biliary tract cancers were higher compared to those in the control group, while the concentrations of TC, HDL, LDL and ApoA were lower than those in the controls. Among female subjects with cholelithiasis, the levels of HDL and ApoA were statistically different among patients of biliary tract cancers, gallstone disease patients and normal controls. For female subjects without gallstones, the mean concentrations of HDL and ApoA among biliary tract cancers patients were significantly lower than those in normal controls. Conclusion: For both genders, lipoprotein metabolism abnormalities with hypertriglyceridemia and low serum levels of HDL were observed among biliary tract cancers.更多还原