【摘要】 外周T细胞淋巴瘤,非特指型(peripheralT-celllymphoma-unspecified,PTCL-U)是新近WHO淋巴肿瘤病理分类中一个较新的亚型。它是起源于胸腺后T淋巴细胞的一类恶性肿瘤。病因不清,可能与Epstein-Barrvirus(EBV)和人类T细胞白血病/淋巴瘤病毒-Ⅰ(HTLV-Ⅰ)有关。其诊断需结合临床、细胞形态、免疫及遗传学特征,并排除其它特指型T细胞淋巴瘤。常规化疗疗效不佳,易复发,5年生存率22%～27%,应寻找更有效的治疗方法。更多还原

【Abstract】 Peripheral T-cell lymphoma-unspecified (PTCL-U) is a new subtype based on WHO classification of lymphoid neoplasms. PTCL-U is a group of malignancies originating from post-thymic T-cells, with poor prognosis and without ideal therapeutic regimen. Recent reports suggest that it is associated with EBV and HTLV-Ⅰ. The diagnosis for the disease requires the characteristics of clinical symptoms, histology, phenotype and genotype feature, with exception of others specified T-cell lymphomas. Current treatment modalities for PTCL-U patients can’t achieve satisfactory outcomes, and the 5-year overall survival rate is approximately 22%~27%%. The optimal therapy for the patients needs to be explored.更多还原