【摘要】 目的:探讨细胞周期蛋白CyclinD1外显子4(870A/G)多态性与儿童急性淋巴细胞白血病(ALL)的相关性。方法:采用聚合酶链反应(PCR)和PCR-RFLP方法,分析183例儿童ALL患者和190例健康对照者的CyclinD1基因型。结果:与健康对照组相比,携带AA基因型者患ALL的相对风险度增加3.2898(P=0.0207);携带AA型的T-ALL患者显著高于B-ALL患者(P=0.047);携带AA型的ALL高危患者显著高于标危患者(P=0.011)。结论:Cy-clinD1基因多态性与中国儿童ALL的发生、发展及预后密切相关。更多还原

【Abstract】 Objective: To approach the dependability between polymorphism of the exon 4(870 A/G) of cyclin D1 and Acute Lymphoblastic Leukemia (ALL) in children. Methods: A case-control study consisting of 183 children ALL patients and 190 controls in a Chinese population was performed to examine the genotypic frequency of the cyclin D1 polymorphism. Results: The genetic frequency of cyclin D1 significantly correlated with overall patients and controls. AA genotype of cyclin D1 showed a tendency to increase ALL risk by 3.289 8-fold compared to AG + GG (P=0.020 7). Stratification of patients according to cell type, risk level and the chemotherapeutic response showed that the AA genotype was clearly observed in T-ALL, and the ALL with high risk (P=0.047 and P= 0.011 respectively). No gene dosage effect was observed in this study. Conclusion: The cyclin D1 genetic polymorphism might be closely related to the occurrence of children ALL in the Chinese population.更多还原