【摘要】 目的评价胃癌术后口服沙培林对胃癌远期疗效的影响。方法152例符合条件的胃癌手术后患者随机分为两组,单纯化疗组(对照组)75例,化疗加沙培林组(观察组)77例。对照组采用标准DF方案,观察组用DF方案加口服沙培林,进行前瞻性对比观察和为期5年的远期疗效评价。结果两组的毒性反应差异无显著性。远期疗效1,2,3,5的生存率观察组分别为84.4%(65/77)、75.3%(56/77)、67.5%(52/77)和61.0%(47/77);对照组分别为82.7%(62/75)、61.3%(46/75)、50.7%(38/75)和46.7%(35/65)。两组比较2,3,5年生存率差异均有显著性(P<0.05)。结论胃癌术后口服沙培林具有较好的耐受性和安全性,毒副作用无增加,主要仍表现为化疗药物的毒副作用,其远期疗效优于单纯化疗组。更多还原

【Abstract】 Objective To evaluate the effect of oral administration of sapylin(OK-432) on long-term therapeutic effectiveness of postoperative stomach cancer.Methods A randomized clinical trial was undertaken to compare routine chemotherapy(DF regimen) and routine chemotherapy plus sapylin.152 cases with stomach cancer were observed and divided into 2 groups:77 cases in experimental group,using sapylin and DF regimen,75 cases in control group using DF alone.Results Minor side effect and toxicity showed no significant difference between the 2 groups.The one-year survival rate,2-year survival rate,3-year survival rate and 5-year survival rate were 84.4%(65/77),75.3%(56/77),67.5%(52/77),61.0%(47/77)in experimental group,respectively,and 82.7%(62/75),61.3%(46/75),50.7%(38/75),46.7%(35/65) respectively in control group.Concluslons Oral administration of sapylin(OK-432) plus routine chemotherapy regimen is more effective than routine chemotherapy regimen alone in treatment of postoperative stomach cancer.Sapylin is safe and effective.更多还原