【摘要】 目的观察肾上腺素、谷氨酸和碳酸氢钠对放射性口腔黏膜反应的治疗作用。方法40例鼻咽癌患者随机分为治疗组、对照组,各20例,进行疗效对比观察,两组放疗均采用面颈联合野加下颈切线野,2.0 Gy/次,5次/周,剂量达到40 Gy后面颈联合野后界前移以避开脊髓,或改为耳前野加全颈切线野,总剂量68~76 Gy/7~8周;治疗组放射治疗前10~15 m in用肾上腺素溶液喷洒口腔黏膜,5 m in后,先在口中含0.5 g谷氨酸,然后再含5%碳酸氢钠溶液5~10 m l在口中,放疗结束后咽下或吐出。结果按CTC 2.0版毒性分级标准,治疗组与对照组的黏膜反应发生率分别为0级5例和0例,1级14例和8例,2级1例和9例,3级0例和3例,两组均无4级毒性发生。两组比较差异有极显著性(P<0.001)。结论局部应用肾上腺素、谷氨酸和碳酸氢钠对放射性口腔黏膜反应有较好的预防和治疗作用。更多还原

【Abstract】 Objective To evaluate the effect of adrenaline,glutamic acid and sodium bicarbonate dissolved in the mouth on radiation mucositis.Methods Forty nasopharyngeal carcinoma patients were divided randomly into two groups: 20 cases in treatment group and 20 cases in control group.All patients received conventional radiation therapy of 2.0 Gy/f,5f/W.The total tumor dose was 68-76 Gy/7-8 W.The patients of treatment group were treated with adrenaline powder on oral cavity surface first,andthen with glutamic acid and sodium bicarbonate dissolved in the mouth before irradiation.Results According to CTC 2.0 toxicity grading criteria,the incidence of mucositis was 5 cases of grade 0,14 cases of grade 1,1 case of 2 grade in treatment group and 8 cases of grade 1,9 cases of grade 2 and 3 cases of grade 3 in control group.There was significant difference between the two groups(P<0.001).Conclusion Taking adrenaline,glutamic acid and sodium bicarbonate dissolved in the mouth is an effective method for prevention and treatment of radiation mucositis.更多还原