【摘要】 目的获得(一级并行)米氏消除药物血管外给药的方案设计。方法根据四阶Runge-Kutta算法,采用Excel软件编写基于药动学参数的给药方案设计程序。结果输入药动学参数Vm,Km,Vd/F,Ke,Ka和给药间隔τs后,Excel规划求解获得最大维持剂量(dmax)和最低维持剂量(dmin);输入选定的维持量(d)及初始浓度后,电子表格显示某周期(或稳态)任一次给药后相隔时间为0.005 h的血药浓度和AUC值,获得有效血药浓度时间(tec)和达坪分数[f(n)],Excel单变量求解获得负荷剂量。结论该方法编程简单,使用方便,既能为临床用药提供安全有效的剂量,又能对某一用药方案作出评价。更多还原

【Abstract】 OBJECTIVE To establish a method for the dosage regimen design of drugs obeying first order absorption and Michaelis-Menten clearance kinetics.METHODS By four stages Runge-Kutta algorithm and Microsoft Excel,the program of dosage regimen design was written on the basis of pharmacokinetic parameters.RESULTS After inputting the pharmacokinetic parameters(V_m,K_m, V_d/F,ke and ka)and dosing interval(τ_s),maximum maintenance dose(d_max) and minimum maintenance dose(d_min) was obtained.After inputting maintenance dose selected between d_max and d_min,plasma concentrations at 0.005 h interval after the administration were displayed.The fractional number of reaching plateau（f） and effective concentration time(t_ec) were obtained.The loading dose was obtained by single variable solution.CONCLUSION This simple program provids safe and effective dosage for clinical drug-use.更多还原