【摘要】 目的探讨在实验性糖尿病大鼠体内联用18α-甘草酸二铵（DG）和格列本脲（Gli）时,DG对Gli药动学的影响。方法采用RP-HPLC测定实验性糖尿病大鼠单用Gli及与DG联用后Gli的血药浓度。用DAS软件进行药动学分析,比较两组Gli药动学参数的变化。结果DG与Gli联用后,Gli的Ke值较单用时明显减少（P＜0.01）,而ρ_max,AUC_0-∞和t_1/2（Ke）则显著增加（P＜0.01）。其余各药动参数差异无显著性。结论DG可抑制Gli的代谢,使其进入血循环总量增加,消除延缓,但不影响Gli的吸收。提示两药联用时应注意调整剂量,避免不良反应发生。更多还原

【Abstract】 OBJECTIVE To study the effect of 18α-diammonii glycyrrhizinatis（DG）on pharmacokinetics of glibenelamide（Gli）in exper- imental diabetic rats.METHODS The Gli concentration in rat plasma was determined by RP-HPLC after administrations of Gli and DG+ Gli.The pharmacokinetics of Gli was analyzed by DAS software and the main pharmacokinetic parameters were compared in the two groups. RESULTS In the rats treated with DG+Gli,the pharmacokinetic parameters Ke of glibenclamide was decreased whileρ_max,AUC_0-∞ and t_1/2Ke were increased significantly,compared with Gli-treated group.There was no significant difference between other parame- ters.CONCLUSION DG may inhibit the metabolism of Gli.So the total amount of Gli in circulation increases and the elimination process is prolonged.But DG has no influence on the absorption of Gli.The dosage of administration may be paid more attention to avoiding adverse reac- tions.更多还原