【摘要】 目的:探讨淋巴细胞浸润在扁平苔藓(LP)发病机制中的作用。方法:免疫组织化学SP法对32例LP患者及30例正常人皮肤CD3,CD4,CD8,CD20进行检测。结果:表皮中浸润细胞以CD3+T,CD8+T细胞为主,真皮以CD3+T,CD4+T,CD8+T细胞为主,真皮乳头浸润细胞多于表皮突。随病程延长,浸润细胞数减少(P<0.01),真皮CD4+/CD8+值下降(P<0.05),CD20+B细胞百分率上升(P<0.05)。有过度增殖性改变的皮损中CD20+B细胞明显增多。结论:CD8+T细胞与LP皮损的基底细胞损伤以及皮损的持续存在有关。皮损局部CD4+T,CD8+T细胞功能失衡。CD20+B细胞可能与疾病的持续存在及局部过度增殖性改变有关。更多还原

【Abstract】 Objective: To investigate the role of infiltrating lymphocytes in the cutaneous lesions of lichen planus(LP).Methods: The expressions of CD3,CD4,CD8,and CD20 were detected by immunohistochemical SP method in 32 LP patients with cutaneous lesions and 30 normal subjects.Results: In the epidermis,the infiltrating lymphocytes were mainly CD3~+ and CD8~+ T cells and(CD20~+) B cells were found by chance.The predominant cells in the dermis were CD3~+,CD4~+,and CD8+ T cells.With the prolongation of the disease course,the number of infiltrating lymphocytes in the cutaneous lesions reduced(P<0.01),the ratio of CD4~+ to CD8~+ T cells in the dermis decreased(P<0.05),and the proportion of CD20~+ B cells increased(P<0.05).The number of CD20~+ B cells markedly increased in LP patients with hyperplastic changes.Conclusion: CD8~+ T cells are associated with the cutaneous lesions of LP.Imbalance of CD4~+ and CD8~+ T cells exists in the cutaneous lesions.CD20~+ B cells may be related to the continuous immune response and excessively hyperplastic changes in the cutaneous lesions of LP.更多还原