【摘要】 目的探讨老年短暂性脑缺血发作(TIA)与血清脂蛋白(a)[Lp(a)]和血浆D-二聚体的关系。方法92例老年TIA患者按病程划分为A、B、C3组,所有病例在起病24h内检测血清Lp(a)和D-二聚体的含量,观察72h内头CT或MRI后与正常对照组进行比较。结果老年TIA患者血清Lp(a)和D-二聚体的含量明显高于正常对照组(P<0.01),B、C组Lp(a)和D-二聚体的含量均高于A组(P<0.01),而且C组高于B组(P<0.05),重型TIA患者明显高于轻、中型患者。TIA各组Lp(a)与D-二聚体含量均呈显著正相关,P均<0.01。结论Lp(a)和D-二聚体含量的升高可以对老年TIA患者的诊断、治疗和估计预后提供较可靠的实验室指标。更多还原

【Abstract】 Objective: To investigate the relationship between the levels of serum lipoprotein (a) and plasma D-dimer and transient ischemic attack (TIA) in aged people. Methods: Ninety-two aged patients with TIA were divided into 3 groups: group A (TIA persisted ≤ 60 minutes and then relieved), group B (TIA persisted > 60 minutes and repeated), and group C (TIA developed into cerebral infarction 24 hours after the onset of TIA). The levels of serum lipoprotein (a) and plasma D-dimer were detected within 24 hours of TIA onset. Head CT or MRI was carried out within 72 hours of TIA onset. Results: The levels of serum lipoprotein (a) and plasma D-dimer in aged patients with TIA were significantly higher than those in normal controls ( P <0.01). The levels of serum lipoprotein (a) and plasma D-dimer in group B and C were higher than those in group A ( P <0.01), and in group C the levels were higher than those in group B ( P <0.05). The plasma D-dimer level positively related to serum lipoprotein (a) level in TIA patients. Conclusion: The increase of the levels of serum lipoprotein (a) and plasma D-dimer may provide reliable evidence for the diagnosis, treatment, and prognosis of TIA in aged people.更多还原