【摘要】 目的研究抗溃疡新药泰妥拉唑的合成。方法以2,6-二氯吡啶为起始原料,经硝化、氨解、取代、还原、环合、烃化、氧化7步反应合成泰妥拉唑(1)。结果与结论以总收率23.3%合成了泰妥拉唑,其结构经核磁共振氢谱、质谱确证。更多还原

【Abstract】 Aim To study the synthesis of tenatoprazole,an antiulcer drug.Methods Starting from 2,6-dichloropyridine,tenatoprazole was obtained via seven steps,such as nitration,ammoniation,substitution,reduction,cyclization,alkylation,and oxidation.Results and conclusion The total yield was 23.3%.The structure of the target compound was established by()~1H-NMR and MS spectra.更多还原