【摘要】 目的设计合成一系列NO供体型奥丙嗪,并考察它们的体外NO释放活性与抗炎活性。方法以奥丙嗪为原料,利用其羧基将奥丙嗪与呋咱环结构或硝酸酯结构偶联起来,得到NO供体型奥丙嗪。结果与结论合成11个NO供体型奥丙嗪衍生物,其中化合物Ⅰa、Ⅰg和Ⅱa~Ⅱd6个化合物为新化合物,目标化合物的结构经MS和1H-NMR确认。呋咱环型化合物在体外能有效地释放出NO,大多数化合物仍保持抗炎活性。更多还原

【Abstract】 Aim To design and synthesize a serial of NO-releasing oxaprozin derivatives,and to study their NO-releasing ability in vitro and their anti-inflammatory activities.Methods NO-releasing oxaprozin derivatives were synthesized by coupling oxaprozin with furoxan or nitrate ester moieties through the carboxyl group of oxaprozin.Results and conclusion NO-releasing oxaprozin compounds were synthesized.Among these,Ⅰa,Ⅰg and Ⅱa～Ⅱd are new compounds.The target compounds were confirmed by MS and()~1H-NMR.Furoxan-type compounds can release NO effectively in vitro,and most of the target compounds maintain anti-inflammatory activities.更多还原