【摘要】 目的探讨前列腺素E1对肺过度膨胀所致损伤的保护作用及作用机制。方法杂种犬16只,随机分为对照组和实验组,建立肺过度膨胀动物模型。对照组:保持肺过度膨胀6h;实验组:保持肺过度膨胀6h,并以30ng/(kg·min)的剂量给予前列腺素E1,6h后取标本进行肺组织湿/干比、支气管肺泡灌洗液中蛋白含量的检测,并进行肺组织光镜和电镜的观察,观察肺损伤的变化情况。结果对照组肺组织湿干比、支气管肺泡灌洗液中蛋白含量(BALF)明显高于实验组(P<0.05);肺组织学检查:实验组肺损伤程度明显轻于对照组。结论前列腺素E1对犬肺过度膨胀所致损伤有明显的保护作用,其作用机制与抑制中性粒细胞活性,降低中性粒细胞、血小板聚集等有关。更多还原

【Abstract】 Objective To explore the protective effect of prostaglandin E₁（PGE₁） on lung and its possible mechanism during lung hyperinflation injury.Methods Sixteen mongrels were randomly divided into control group（C）and PGE-n=1 group（P）and lung hyperinflation canine model was established.Lung hyperinflation was kept in control group for 6 hours,and on the basis of the former the PGE₁ group was given 30 ng/kg/min PGE₁.The changes of lung tissue wet weight/dry weight ratio（W/D）and total protein content of bronchoalveolar lavage fluid（BALF） were measured after 6 hours; the histological appearances of the lung tissue and the pulmonary vascular were observed under histology and electron microscopy.Results W/D and total protein content of BALF were significantly higher in control group than in PGE₁ group（P<0.05）; histological examination of lung tissue demonstrated that the degree of lung injury was worsen in PGE₁ group than in control group.Conclusion PGE₁ can significantly attenuate the lung hyperinflation injury,which protective mechanism may be that PGE₁ can inhibit aggregation of neurotrophilic granulocyte and platelet in the lung.更多还原