【摘要】 目的探讨成人迟发性自身免疫糖尿病(LADA)的临床特点,提高对此病的认识。方法回顾性分析24例LADA患者的临床资料和实验室指标。结果LADA起病年龄范围广,易发生自发酮症。部分LADA患者体形肥胖,可伴有脂代谢紊乱、高血压。LADA患者C肽水平明显降低或在正常范围低限水平,谷氨酸脱羧酶抗体(GADA)阳性率高。日用胰岛素剂量差别大。结论LADA可发生于成人各年龄段,部分患者可合并代谢综合征(MS)。C肽及GADA测定可协助早期正确分型。LADA患者需胰岛素治疗,对于伴代谢综合征胰岛素抵抗者需联合应用改善胰岛素敏感性的药物,纠正脂代谢紊乱是有必要的。更多还原

【Abstract】 Objective To study the clinical characteristics of late autoimmune diabetes in adults(LADA),and to improve the understanding of this disease.Methods Clinical data and laboratory parameters of 24 LADA cases were analyzed retrospectively. Results The range of LADA patients′ onset age was wide and LADA tended to develop into spontaneous ketosis.Some LADA patients were obesity and were complicated with lipid metabolic disorders and high blood pressure.The levels of plasma C-peptide were obviously lower or at the bottom line of the normal range.The positive rates of glutamic acid decarboxylase autoantibody (GADA) were markedly higher.The doses of insulin injected subcutaneously per day were more significantly different. Conclusion Adults at different ages have possibility of suffering from LADA and some patients have metabolic syndrome (MS).C-peptide and GADA screening are necessary for early etiological classification.LADA patients need insulin,which with MS need insulin sensitizers to correct lipid metabolic disorders.更多还原