【摘要】 流行病学统计显示,吸烟者患帕金森氏综合症(PD)和老年痴呆症(AD)的概率远低于不吸烟者,但是其机理还不清楚。我们研究发现:(1)烟碱可以有效清除活性氧自由基,能够抑制多巴胺自氧化,是一个抗氧化剂。(2)烟碱能够有效抑制6OHDA和MPP+诱导的线粒体肿胀和细胞色素C(Cyt.C)释放。(3)烟碱可以保护海马神经元抵抗Aβ淀粉样蛋白诱导细胞的凋亡。(4)烟碱可以防止淀粉样蛋白在转基因AD鼠脑沉淀。(5)烟碱可以络合金属铜防止和减少其在脑中积聚。这对于解释烟碱防治神经退行性疾病AD和PD机理具有重要意义。更多还原

【Abstract】 Epidemic results show that cigarette smoker has decreased risk of developing Parkinson’s disease (PD) and Alzheimer’s disease (AD) although the mechanism has not been identified. Current study found that: (1) Nicotine scavenged hydroxyl and superoxide free radical and inhibit oxidation of 6-OHDA. (2) Nicotine inhibited the oxidation of 6-OHDA and N-methyl-4-phenylpyridine (MPP +) induced mitochondria high-amplitude swelling and cytochrome C released from intact mitochondria. (3) Nicotine protected cultured hippocampal neurons against A(βinduced apoptosis. (4) Nicotine prevented Aβ and copper deposition in the brain of transgenic APP V7171 mouse. These results are of great importance in explaining the preventive effects of nicotine against cell apoptosis in neurodegenerative diseases.更多还原