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抗病毒口服液的质量标准研究
Study on Quality Standard for Kangbingdu Oral Solution
【摘要】 目的:建立抗病毒口服液的质量标准。方法:采用薄层色谱法对抗病毒口服液中的金银花、鱼腥草、赤芍和射干进行定性鉴别;以高效液相色谱法对其金银花中的绿原酸进行含量测定。结果:抗病毒口服液的金银花、鱼腥草、赤芍、射干薄层色谱中,在与对照药材相应的位置上显相同颜色的斑点;绿原酸检测浓度在3.66~73.20μg/ml范围内与峰面积积分值线性关系良好(r=0.9998),平均回收率为99.7%(RSD=1.52%)。结论:所建质量标准可用于本品的质量控制。
【Abstract】 OBJECTIVE:To establish the method for quality control of Kangbingdu oral solution.METHODS:TLC was used to identify 4 Chinese medicines,which were Flos Lonicerae,herba houttuyniae,radix paeoniae rubra and rhizoma belamcandae.HPLC was used to determine the content of chlorogenic acid of Flos Lonicerae.RESULTS:In the TLC of flos lonicerae,Herba houttuyniae,Radix paeoniae rubra and rhizoma belamcandae,spots of same color were identified in the corresponding position.The linear range of chlorogenic acid was 3.66~73.20μg/ml(r=0.9 998).The average recovery was 99.7% and the RSD was 1.52%.CONCLUSION:The method was simple,accurate and with strong specificity and could be used to control the quality of this preparation.
【Key words】 Kangbingdu oral solution; TLC; HPLC; Chlorogenic acid; Quality standard;
- 【文献出处】 中国药房 ,China Pharmacy , 编辑部邮箱 ,2006年20期
- 【分类号】R286.0
- 【被引频次】5
- 【下载频次】337