【摘要】 目的:研究以界面聚合法制备齐墩果酸聚氰基丙烯酸正丁酯纳米囊(OA-PBCA-NC)的处方工艺条件,并考察其质量。方法:采用单因素法筛选界面聚合法制备OA-PBCA-NC的工艺,并以包封率为指标,用正交设计试验,优选OA-PBCA-NC的处方。另对其进行形态、粒径、包封率考察。结果:本品处方以OA与BCA用量比为60mg∶0.1ml,乙酸乙酯与BCA用量比为2.0ml∶0.1ml,油水两相比为1∶1为最佳;制得纳米囊外观圆整,较均匀,无粘连;粒径分布均匀,平均粒径率为(214±8)nm,平均包封率为(76.8±0.4)%。结论:本研究所确定的OA-PBCA-NC制备工艺条件稳定,可行。更多还原

【Abstract】 OBJECTIVE:To optimize the formula and preparation technique of oleanolic acid loaded polybutylcyanoacrylate nanocapsules(OA-PBCA-NC)by interfacial polymerization and to study its quality.METHODS:The preparation technique of OA-PBCA-NC prepared by interfacial polymerization were optimized by single factor design,and the formula was optimized by orthogonal design with entrapment ratio as index.Its shape,particle size and the entrapment ratio were investigated as well.RESULTS:The optimized dosage ratios were as follows∶ OA vs.BCA∶60mg∶0.1ml;acetic ether vs.BCA∶2.0ml∶0.1ml;and oil vs.water:1∶1.The prepared nanocapsules were round and regular in shape without adherence.The particle size was well-distributed with mean diameter at(214±8)nm and mean entrapment ratio at(76.8±0.4)%.CONCLUSION:The preparation technique of OA-PBCA-NC established in this study is stable and feasible.更多还原