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龟板体外抗氧化活性的研究

Study of Antioxidant Activities of Plastrum Testudinis in Vitro

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【作者】 谢学明李熙灿钟远声黄春花杜少辉李伊为陈东风

【Author】 XIE Xueming,ZHONG Yuansheng,HUANG Chunhua(College of Chinese Materia Medica,Guangzhou University of Traditional Chinese Medicine,Guangzhou510006,China) LI Xican(Dept.of Chemistry,College of Chinese Materia Medica,Guangzhou University of Traditional Chinese Medicine,Guangzhou510006,China) DU Shaohui(Dept.of Internal Medicine,Shenzhen Municipal Hospital of Traditional Chinese Medicine,Shenzhen 518033,China) LI Yiwei,CHEN Dongfeng(Dept.of Anatomy,College of Preclinical Medicine,Guangzhou University of Traditional Chinese Medicine,Guangzhou510405,China)

【机构】 广州中医药大学中药学院广州中医药大学中药学院化学教研室广东省深圳市中医院内科广州中医药大学基础医学院解剖学教研室广州中医药大学基础医学院解剖学教研室 广州市510006广州市510006深圳市518033广州市510405

【摘要】 目的研究龟板的体外抗氧化活性,为抗衰老药物的筛选提供参考。方法将龟板分别用石油醚、乙酸乙酯、95%乙醇等极性依次递增的溶剂进行提取得不同提取部位溶出物,用DPPH法进行体外抗氧化活性检测,并与抗坏血酸进行比较。结果龟板95%乙醇提取部位溶出物与石油醚、乙酸乙酯部位提取物相比抗氧化活性均存在显著性差异(P<0.01),且以95%乙醇提取部位溶出物体外抗氧化活性最强,其EC50与抗坏血酸比较相差2.38个数量级。结论龟板95%乙醇提取部位溶出物具有很强的体外抗氧化活性,可作进一步研究。

【Abstract】 OBJECTIVE:To study the antioxidant activities of Plastrum Testudinis in vitro so as to provide references for the optimization of antiaging agents.METHODS:Extracts from different parts were extracted from Plastrum Testudinis with polarity progressive solvents in order:petroleum ether,ethyl acetate and 95% ethanol,respectively.Then in vitro antioxidant activities of the extracts were detected by DPPH method and compared with antiscorbic acid(Vit C).RESULTS:Significant differences were noted between the extracts by 95%ethanol ether and those by petroleum ether or ethyl acetate in antioxidant activities(P<0.01),with that extracted by 95% ethanol showing the highest antioxidant activities.2.38orders of magnitude difference was noted compared to Vit C in terms of EC 50 .CONCLUSION:The extracts of Plastrum Testudinis extracted by95%ethanol exhibits a strong antioxidant activity in vitro,which remains to be further studied.

【关键词】 龟板DPPH抗氧化活性
【Key words】 Plastrum TestudinisDPPHAntioxidant activities
【基金】 国家自然科学基金项目(30371837、30472272);广东省自然科学基金项目(31483)
  • 【分类号】R285
  • 【被引频次】53
  • 【下载频次】486
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