【摘要】 目的:研究酮洛芬巴布剂的最优处方并考察其影响因素。方法:采用正交试验法设计处方,拉力机测定粘着强度,利用Franz扩散池考察体外经皮渗透性。结果:筛选出最优处方,其粘着强度为40N,稳态流量为9·72μg/(cm2·h)。结论:建立的巴布剂制备工艺合理、稳定,粘着强度和透皮效果为其主要质量影响因素。更多还原

【Abstract】 OBJECTIVE:To optimize the matrix formulation of ketoprofen cataplasm and to investigate its influencing factors.METHODS:Orthogonal design was used to design formulations,adhesive stress was tested with the tension meter and the per cutem permeability in vitro was studied using the franz diffusion cell.RESULTS:The optimal poultice was acquired with adhesive stress at40N and steady permeation flux at9.72μg/(cm 2 ·h).CONCLUSION:The established preparation technique of poultice is stable and feasible,and its leading influencing factors are adhesive stress and transdermal effects.更多还原